Do-Si-Dos Strain and Grow Guide

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Written By Rocky Horton

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The Do-Si-Dos strain danced onto the scene in 2016 and quickly became one of the most well-known and sought-after Indica-dominant strains on the market. It’s now as famous for its spicy-sweet flavor palette as it is infamous for its sky-high THC levels, which some labs show as high as 30%.

Users hoping to ward off pain and depression find a calming, cerebral head high with Do-Si-Dos. Many list couchlock as a potential side effect, so only use Do-Si-Dos when you can sleep it off. If you feel ready, continue reading to learn about the particulars of this newish West coast favorite.

Where Does Do Si Dos Come From?

The Do Si-Dos strain comes from a combination of Girl Scout Cookies, one of the most famous strains out there, and Face Off OG, an Indica-dominant phenotype of OG Kush. Its original breeder was the Archive Seed Bank, based in Portland, Oregon. It’s been sweeping down the West coast ever since.

The combination of Cookies and Kush genetics produces effects that dance circles around its users’ heads. This should be no surprise coming from Face Off OG, named after the Nic Cage and John Travolta film where they swapped faces. The strain is infamous for creating crazy variants and Do-Si-Dos is no different.

When Did Do-Si-Dos Come Out?

Archive Seed Bank created the Do-Si-Dos strain in 2016. These breeders are based in Portland, Oregon but bring their experienced passion for genetic variety to a myriad of products throughout the mid-West. They’ve been growing for the North American market for over 35 years, so Do-Si-Dos is a product not only of passion but also of decades of experience.

Other hybrids from the Face Off OG lineage like Designer OG and Rocket Fuel prepared the way for Do-Si-Dos to be the major hit that it’s become in the years since it’s been available.

What Does Do-Si-Dos Look Like?

Do-Si-Do grows with long, cone-shaped buds that are dark green like olives and scattered with dull amber hairs. Its leaves range from dark green to tinges of purple, all coated in a layer of sweet trichome resin, like a white frost. This high resin production makes Do-Si-Dos ideal for growers that want to source their crops for high-quality concentrates.

Importantly, the temperature at which the strain is grown can alter its color. Growers that want to draw out the strain’s potential for purple hues should slightly lower the environmental temperature before the flowering phase.

What Does Do-Si-Dos Taste Like?

Do-Si-Dos has a flavor that tastes like bright lemon citrus at first, but eventually produces additional tastes of diesel fuel, pine, nuts, lime, and berries with an aftertaste of earthy herbs. There’s also a tinge of cookie flavor with a floral aftertaste.

The result is nutty, herbal, sweet, and fermented. These tastes come from the Do-Si-Dos strain’s dynamic terpene profile, which includes beta-caryophyllene, linalool, beta-myrcene, and alpha-humulene, with trace amounts of alpha-pinene and terpinolene. We recommend the Do-Si-Dos strain’s complex tastes, as well as its high potency (see below), for more experienced users.

What Does Do-Si-Dos Smell Like?

Do-Si-Dos smells similarly to its flavor, with a tinge of lime, pine, and an aftereffect of nutty fuel. The aroma also contains a clear scent of mint that adds to the strain’s outdoorsy freshness. Be prepared for a cloud of heavy, dank smoke, which fills the room with this aroma a little more with each smooth exhale. Users looking for a discreet strain should look elsewhere.

Note that the Do-Si-Dos strain has a strong smell of citrus pine even while growing, so growers will need to maintain an efficient ventilation system to prevent it from becoming overpowering.

Is Do-Si-Dos an Indica or Sativa?

Do-Si-Dos is an Indica-dominant strain in a 70/30 proportion, which shouldn’t be surprising since its lineage contains so many Indica favorites. This results in a strain that tends to grow shorter and focuses the potency of its high on the user’s head, leading to cerebral effects that affect the user’s sleep schedule, consciousness, and mental state.

Strains that have similar effects to Do-Si-Dos also tend to be Indica-dominant. These strains include Mendo Breath, Secret Formula, Cement Shoes, Jelly Breath, and more. 

What are the Different Variations of Do-Si-Dos?

The Do-Si-Dos strain is sometimes listed as “dosi” or “dosidos,” but “variations” in this case refer to genetically altered versions of the strain. For example, Do-Si-Dos combined with Cookies Auto becomes Do-Si-Do Automatic, a version of the strain that has a much faster life cycle.

Other variations of the strain include Do-Si-Dos Cake, Do-Si-Dos Auto, Do-Si-Dos Fast, Do-Si-Dos OG, Do-Si-Dos #18, Do-Si-Dos Cake Autoflowering, Cherry Do-Si-Dos, and Double Do-Si-Dos. The popularity of the original version has made these variations as plentiful as they are delicious.

Which Do-Si-Dos Variation is the Strongest?

The variations of Do-Si-Dos range in strength. Do-Si-Dos Cake, for instance, has a THC level of up to 28% or more, making it comparable with the original strain. Other variations, however, such as Do-Si-Dos OG, can have considerably less THC content, around 19% (which is still intense, depending on your experience).

A commonality between the testing of many of the Do-Si-Dos variants is a wide range of values, with many testing 10% different depending on the crop. This means that the crop of Do-Si-Dos makes a bigger difference than the variation, though the original still consistently tests the highest.

How Much THC in Do-Si-Dos?

Do-Si-Dos has a THC level of 19-30%, meaning that even the average crop of this strain hovers in the mid-20s. This makes the Do-Si-Dos strain ideal for experienced users who know what they’re getting into.

We recommend Do-Si-Dos for nighttime use due to these extreme levels. However, the strain pairs well with a do-nothing day as well, such as a spa or yoga day, or a day when you can mostly just sleep and relax.

How Much CBD in Do-Si-Dos?

Do-Si-Dos can contain anywhere from 0.5% to 2% CBD. CBD, also known as cannabidiol, is an active chemical compound that activates the bud’s medicinal potential, fighting inflammation, stress, pain, and other factors.

An increase in CBD does, however, increase the potential for a strain to have side effects such as fatigue and irritability, as well as the potential for blood thinning, which may interact with certain medications. Users on certain medications or who are inexperienced in the effects of CBD should air on the side of caution with a strain as potent as Do-Si-Dos.

What Effects Does Do-Si-Dos Have?

The Do-Si-Dos high is fast-acting, with users feeling tingling almost immediately after smoking. As its cerebral effects sink in, the strain encourages users to feel like their thoughts are clear and fluent, while leading them inevitably to sedation.

To accompany this cerebral euphoria, Do-Si-Dos relieves its users of depression and improves their mood. This can lead to feelings of relaxation that drift to sedation and couchlock. Feeling hungry and sleepy is also common on Do-Si-Dos, which is why experience level plays a big part in deciding when the strain should be used and in what dose.

What Conditions is Do-Si-Dos Good For?

Do-Si-Do’s effects can help users reduce pain through mental stimulation. The strain helps users focus on creative tasks and erase their negative thoughts. Therefore, conditions that Do-Si-Dos has been known to help alleviate include depression, stress, ADHD, and mood disorders.

Since hunger is a frequently mentioned side effect of the strain, a loss of appetite related to stress, medical treatment, or mood disorders can also be treated with Do-Si-Dos. Since using this strain usually ends with being locked to your couch in feelings of stoney sedation, even insomnia can be treated with Do-Si-Dos.

What is the Do-Si-Dos Veg Time?

The veg time for Do-Si-Dos could be anywhere from 4-8 weeks, depending on the conditions in the growing area. Do-Si-Dos is known to start producing some flowers between weeks 4 and 5 of the veg stage, but growers should note that those plants will likely remain shorter.

As an Indica-dominant strain, growers can expect Do-Si-Dos to remain relatively short even as it stretches out in its vegetative phase, though this naturally varies with the size of the containers you use.

What is the Do-Si-Dos Flowering Time?

The flowering time for the Do-Si-Dos strain is around 8-9 weeks, which is shorter than the average hybrid strain (many continue flowering for up to 11 weeks). This is owing to the strain’s Indica-dominant genetics, which often shorten the flowering time, while Sativas take longer (often up to 12 weeks) to finish flowering.

The flowering stage is the time to change up the plants’ nutrient profile to promote their transition from growing to budding and flowering. It’s also when growth training techniques such as low stress training become viable, giving experienced growers the chance to maximize their yields.

When to Harvest Do-Si-Dos?

Do-Si-Dos needs around 8-9 weeks before being harvested. Growers will need to examine the strain’s trichomes after the allotted growing time to see if it’s ready. Growers may need to do this closely to time their harvest properly. Do-Si-Dos plants are ready when the trichomes have become partly milky-white and partly amber-colored.

Note that harvesting a little earlier tends to produce strains with a more energizing effect while waiting a little longer tends to give strains a more sedating effect.

How Tall Does Strain Grow?

The Do-Si-Dos plant can grow up to 2.5 meters in height in the wild, but in your growing space it will likely remain at a more manageable, average height of fewer than two meters. This is closer to what growers should expect from an Indica-dominant strain, which tend to be bushier and require different types of trimming techniques.

However, Do-Si-Dos’ mixed genetics can potentially send it in either direction depending on environmental factors. Noting the height at the first sign of flowers can be a good gauge to figuring out how much room you’ll need.

How Much Does Do-Si-Dos Yield?

Do-Si-Dos yields anywhere from 17-21 ounces per square meter, which means that growers can expect an average of 19 when the conditions have been maximized for the strain’s growth potential. This is considered an average yield, the equivalent of about 480-600g per square meter.

Do-Si-Dos is a mid-October harvest, so those environmental conditions may encourage to yield more. For a low-hanging Indica like this, low stress training can also be used to gently change the plants’ shape into one that increases yields by making light distribution more even.


Do-Si-Dos is a strain that comes from infamous parents (GSC and Face Off OG), and this has given it a reputation for exciting flavors and effects. Its slight Indica dominance has given it a cerebral high that users enjoy for its benefits in treating depression, stress, ADHD, mood disorders, and more.

The strain’s potency (up to 30% THC in some cases) also makes it a powerful sedative for those suffering from insomnia. Side effects of the strain include sleepiness and hunger, so it’s recommended to use the strain when you fall asleep if you need to. Keeping snacks handy would be a good idea too.

Its flavors and aromas wield a mix of complex textures against even the most experienced palette. This includes a mix of herbs, nuts, citrus, berries, and a hint of diesel fuel, transforming into a powerful aroma of mint, pepper, herbs, and lemon. Do-Si-Dos more than earns its reputation for deliciousness and backs it up with medicinal effects. With the potential for 30% THC, users just need to make sure they’re prepared to sleep and relax before making this euphoric plunge.

If you like Do Si Dos, be sure to check out Wedding Cake.

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Rocky Horton


Rocky Horton is an experienced cannabis grower and the founder of IndoGrow. The IndoGrow editorial team has over four decades of combined growing experience. Learn more.